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1

Myc deletion rescues Apc deficiency in the small intestine

Sansom, Owen J., Meniel, Valerie S., Muncan, Vanesa, Phesse, Toby J., Wilkins, Julie A., Reed, Karen R., Vass, J. Keith, Athineos, Dimitris, Clevers, Hans, Clarke, Alan R.

Journal:

Year:

2007

Language:

english

File:

PDF, 707 KB

english, 2007

2

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

Julia Bollrath, Toby J. Phesse, Vivian A. von Burstin, Tracy Putoczki, Moritz Bennecke, Trudie Bateman, Tim Nebelsiek, Therese Lundgren-May, Özge Canli, Sarah Schwitalla, Vance Matthews, Roland M. Sch

Journal:

Year:

2009

Language:

english

File:

PDF, 2.22 MB

english, 2009

3

Linking inflammation to cancer – A novel role for Stat3

Matthias Ernst, Toby J. Phesse, Brendan Jenkins, Michael Buchert, Brent McKenzie, Julia Bollrath, Florian R. Greten, Tracy Putoczki

Journal:

Year:

2009

Language:

english

File:

PDF, 106 KB

english, 2009

4

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

Gabrielle H. Ashton, Jennifer P. Morton, Kevin Myant, Toby J. Phesse, Rachel A. Ridgway, Victoria Marsh, Julie A. Wilkins, Dimitris Athineos, Vanesa Muncan, Richard Kemp, Kristi Neufeld, Hans Clevers,

Journal:

Developmental Cell

Year:

2010

Language:

english

File:

PDF, 2.30 MB

english, 2010

5

38 Cited 1 Knockout Mice Have Reduced Growth of Intestinal Tumours

Fei Song, Toby J. Phesse, Alan R. Clarke, Alastair J. Watson

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 49 KB

english, 2009

6

Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism

Zoé D. Burke, Karen R. Reed, Toby J. Phesse, Owen J. Sansom, Alan R. Clarke, David Tosh

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 3.27 MB

english, 2009

7

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

Elsum, I A, Yates, L L, Pearson, H B, Phesse, T J, Long, F, O'Donoghue, R, Ernst, M, Cullinane, C, Humbert, P O

Journal:

Year:

2014

Language:

english

File:

PDF, 6.45 MB

english, 2014

8

Responding to R-Spondin: Slit2 Potentiates Intestinal Regeneration

Phesse, Toby J., Sansom, Owen J.

Journal:

Year:

2013

Language:

english

File:

PDF, 301 KB

english, 2013

9

78

Ernst, Matthias, Phesse, Toby J., Thiem, Stefan, Buchert, Michael

Journal:

Year:

2013

Language:

english

File:

PDF, 43 KB

english, 2013

10

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

Phesse, T J, Myant, K B, Cole, A M, Ridgway, R A, Pearson, H, Muncan, V, van den Brink, G R, Vousden, K H, Sears, R, Vassilev, L T, Clarke, A R, Sansom, O J

Journal:

Cell Death & Differentiation

Year:

2014

Language:

english

File:

PDF, 3.34 MB

english, 2014

11

Normal stem cells in cancer prone epithelial tissues

Phesse, T J, Clarke, A R

Journal:

British Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 245 KB

english, 2009

12

K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse

Pearson, H. B., Phesse, T. J., Clarke, A. R.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 914 KB

english, 2009

13

PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis

Sakthianandeswaren, A., Christie, M., D'Andreti, C., Tsui, C., Jorissen, R. N., Li, S., Fleming, N. I., Gibbs, P., Lipton, L., Malaterre, J., Ramsay, R. G., Phesse, T. J., Ernst, M., Jeffery, R. E., P

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 2.72 MB

english, 2011

14

Deficiency of Mbd2 Attenuates Wnt Signaling

Phesse, T. J., Parry, L., Reed, K. R., Ewan, K. B., Dale, T. C., Sansom, O. J., Clarke, A. R.

Journal:

Molecular and Cellular Biology

Year:

2008

Language:

english

File:

PDF, 2.46 MB

english, 2008

15

Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc

Muncan, V., Sansom, O. J., Tertoolen, L., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., de Alboran, I. M., Clevers, H., Clarke, A. R.

Journal:

Molecular and Cellular Biology

Year:

2006

Language:

english

File:

PDF, 1.66 MB

english, 2006

16

Therapeutic Inhibition of Jak Activity Inhibits Progression of Gastrointestinal Tumors in Mice

Stuart, E., Buchert, M., Putoczki, T., Thiem, S., Farid, R., Elzer, J., Huszar, D., Waring, P. M., Phesse, T. J., Ernst, M.

Journal:

Molecular Cancer Therapeutics

Year:

2014

Language:

english

File:

PDF, 740 KB

english, 2014

17

Cited1 Deficiency Suppresses Intestinal Tumorigenesis

Méniel, Valérie, Song, Fei, Phesse, Toby, Young, Madeleine, Poetz, Oliver, Parry, Lee, Jenkins, John R., Williams, Geraint T., Dunwoodie, Sally L., Watson, Alastair, Clarke, Alan R., Clurman, Bruce E.

Journal:

Year:

2013

Language:

english

File:

PDF, 15.28 MB

english, 2013

18

Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

Hare, Lauren M., Phesse, Toby J., Waring, Paul M., Montgomery, Karen G., Kinross, Kathryn M., Mills, Kevin, Roh, Vincent, Heath, Joan K., Ramsay, Robert G., Ernst, Matthias, Phillips, Wayne A.

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 3.06 MB

english, 2014

19

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt- -catenin-mediated intestinal tumor growth and regeneration

Phesse, T. J., Buchert, M., Stuart, E., Flanagan, D. J., Faux, M., Afshar-Sterle, S., Walker, F., Zhang, H.-H., Nowell, C. J., Jorissen, R., Tan, C. W., Hirokawa, Y., Eissmann, M. F., Poh, A. R., Mala

Journal:

Science Signaling

Year:

2014

Language:

english

File:

PDF, 1.26 MB

english, 2014

20

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsa

Journal:

Stem Cell Reports

Year:

2015

Language:

english

File:

PDF, 2.75 MB

english, 2015

21

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

Infantino, S., Jones, S. A., Walker, J. A., Maxwell, M. J., Light, A., O'Donnell, K., Tsantikos, E., Peperzak, V., Phesse, T., Ernst, M., Mackay, F., Hibbs, M. L., Fairfax, K. A., Tarlinton, D. M.

Journal:

Science Signaling

Year:

2014

Language:

english

File:

PDF, 629 KB

english, 2014

22

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Pearson, Helen B., McGlinn, Edwina, Phesse, Toby J., Schlüter, Holger, Srikumar, Anuratha, Gödde, Nathan J., Woelwer, Christina B., Ryan, Andrew, Phillips, Wayne A., Ernst, Matthias, Kaur, Pritinder,

Journal:

Molecular Cancer

Year:

2015

Language:

english

File:

PDF, 2.04 MB

english, 2015

23

Dual targeting of bromodomain and extra-terminal domain proteins, and WNT or MAPK signaling, inhibits c-MYC expression and proliferation of colorectal cancer cells

To gel, L., Nightingale, R., Chueh, A. C., Jayachandran, A., Tran, H., Phesse, T., Wu, R., Sieber, O. M., Arango, D., Dhillon, A. S., Dawson, M. A., Diez-Dacal, B., Gahman, T. C., Filippakopoulos, P.,

Journal:

Molecular Cancer Therapeutics

Year:

2016

Language:

english

File:

PDF, 8.13 MB

english, 2016

24

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells

Schwab, Renate H. M., Amin, Nancy, Flanagan, Dustin J., Johanson, Timothy M., Phesse, Toby J., Vincan, Elizabeth

Journal:

Developmental Dynamics

Year:

2017

Language:

english

File:

PDF, 1.96 MB

english, 2017

25

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

Flanagan, Dustin J, Vincan, Elizabeth, Phesse, Toby J

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

26

Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo

Flanagan, Dustin J., Barker, Nicholas, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J., Vincan, Elizabeth

Journal:

Disease Models & Mechanisms

Year:

2017

Language:

english

File:

PDF, 2.92 MB

english, 2017

27

Lgr5 joins the club of gastric stem cell markers in the corpus

Phesse, Toby J., Sansom, Owen J.

Journal:

Nature Cell Biology

Year:

2017

Language:

english

File:

PDF, 275 KB

english, 2017

28

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

Phesse, Toby J, Marsh Durban, Victoria, Sansom, Owen J

Journal:

Year:

2017

Language:

english

File:

PDF, 676 KB

english, 2017

29

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation

May, Stephanie, Owen, Heather, Phesse, Toby J, Greenow, Kirsty R, Jones, Gareth-Rhys, Blackwood, Adam, Cook, Peter C, Towers, Christopher, Gallimore, Awen M, Williams, Geraint T, Stürzl, Michael, Brit

Journal:

The Journal of Pathology

Year:

2018

Language:

english

File:

PDF, 1.70 MB

english, 2018

30

Frizzled7: A Promising Achilles’ Heel for Targeting the Wnt Receptor Complex to Treat Cancer

Phesse, Toby, Flanagan, Dustin, Vincan, Elizabeth

Journal:

Year:

2016

Language:

english

File:

PDF, 795 KB

english, 2016

31

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

Flanagan, Dustin, Austin, Chloe, Vincan, Elizabeth, Phesse, Toby

Journal:

Year:

2018

Language:

english

File:

PDF, 1.25 MB

english, 2018

32

Correction for Muncan et al., “Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c- Myc ”

Muncan, Vanesa, Sansom, Owen J., Tertoolen, Leon, Phesse, Toby J., Begthel, Harry, Sancho, Elena, Cole, Alicia M., Gregorieff, Alex, Moreno de Alboran, Ignacio, Clevers, Hans, Clarke, Alan R.

Journal:

Molecular and Cellular Biology

Year:

2018

Language:

english

File:

PDF, 176 KB

english, 2018

33

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Eissmann, Moritz F., Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby, Brunnberg, Jamina, Poh, Ashleigh R., Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas D., Hibbs, Margaret

Journal:

Nature Communications

Year:

2019

File:

PDF, 2.69 MB

2019

34

The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Flanagan, Dustin, Barker, Nick, Ernst, Matthias, Vincan, Elizabeth, Phesse, Toby

Journal:

Year:

2019

Language:

english

File:

PDF, 3.24 MB

english, 2019

35

The Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Flanagan, Dustin, Barker, Nick, Ernst, Matthias, Vincan, Elizabeth, Phesse, Toby

Journal:

Year:

2019

File:

PDF, 3.24 MB

2019

36

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Koushyar, Sarah, G. Powell, Arfon, Vincan, Elizabeth, J. Phesse, Toby

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 1.59 MB

2020

37

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Tran, Bang Manh, Flanagan, Dustin James, Ebert, Gregor, Warner, Nadia, Tran, Hoanh, Fifis, Theodora, Kastrappis, Georgios, Christophi, Christopher, Pellegrini, Marc, Torresi, Joseph, Phesse, Toby Jame

Journal:

Year:

2020

File:

PDF, 1.27 MB

2020